國立臺南護理專科學校護理科資訊網

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名稱劉紋君

辦公室電話740

信箱wenchun911@mail.ntin.edu.tw

授課領域微生物(含實驗)、免疫學、基礎醫學總論

研究專長微生物免疫領域: 病毒學、微生物基因體學、免疫學、生物資訊學、腫瘤醫學。精神醫學領域: 憂鬱症、營養學、臨床醫學研究分析

學校名稱	系所	學位	期間
國立成功大學	基礎醫學研究所	博士	2002-08-2007-09
國立成功大學	分子醫學研究所	碩士(直升博士班)	2001-08-2002-07

服務機關名稱	單位	職務	期間
國立臺南護理專科學校	護理科	助理教授	2024-08-迄今
臺南市立安南醫院-委託中國醫藥大學興建經營	教學研究部	博士後研究員	2023-08-2024-07
國立成功大學	醫學院內科	博士後研究員	2012-08-2023-07
國立成功大學	肝臟醫學生物科技研究中心	助研究員	2011-08-2012-07
明道大學	生物科技學系	助理教授	2008-08-2011-07

年度	論文名稱
2025	Chang CC, Liu WC, Chou PH. Near-Infrared Spectroscopy-Guided Personalized Repetitive Transcranial Magnetic Stimulation for Bipolar Depression: A Case Report. Frontiers in Psychiatry, Front Psychiatry. 2025 Jan 20:15:1514153.doi: 10.3389/fpsyt.2024.1514153.(IF=3.2, Ranking=PSYCHIATRY, 88/279, 31.5%)
2025	Mudiyanselage SPK, Tsai YT, Liu WC, Tsai YJ, Ko NY. Breast cancer and suicide: A comprehensive systematic review and meta-analysis of suicidal behaviours mortality and risk factors among women with breast cancer. J Affect Disord. 2025 Feb 16;376:422-434. doi: 10.1016/j.jad.2025.02.027. (IF=4.9, Ranking=PSYCHIATRY, 38/279, 13.6%)
2025	Chiang CM, Lin YJ, Liu WC, Chou TC, Tsai CH, Chang TT, Wu IC. HBV Recurrence, Occult HBV Infection, and Immune Escape in Chronic Hepatitis B Patients Following Liver Transplantation. Journal of Medical Virology. 2025 (IF=6.8, Ranking=VIROLOGY, 4/41, 9.8%) (2025 March, Accepted)
2025	Chang CH, Hsia YD, Liu WC, Lee JH, Lin CH, Lane HY. Symptomatic and cognitive effects of D-amino acid oxidase inhibitors in patients with schizophrenia: a meta-analysis of double-blind randomized controlled trials. Schizophrenia. 2025 (IF=3.0, Ranking=PSYCHIATRY, 95/279, 34.1%) (2025 March, Accepted)
2024	Liu J, Lv X, Ye T, Zhao M, Chen Z, Zhang Y, Yang W, Xie H, Zhan L, Chen L, Liu WC, Su KP, Sun J. Microbiota-microglia crosstalk between Blautia producta and neuroinflammation of Parkinson's disease: A bench-to-bedside translational approach. Brain Behav Immun. 2024 Mar;117:270-282. doi: 10.1016/j.bbi.2024.01.010. Epub 2024 Jan 9. PMID: 38211635. (IF=8.8, Ranking=PSYCHIATRY, 10/276, 3.6%)
2024	Wang HF, Liu WC, Zailani H, Yang CC, Chen TB, Chang CM, Tsai IJ, Yang CP, Su KP. A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine. Brain Behav Immun. 2024 May;118:459-467. doi: 10.1016/j.bbi.2024.03.019. Epub 2024 Mar 16. PMID: 38499208 (IF=8.8, Ranking=PSYCHIATRY, 10/276, 3.6%)
2024	Yang CP, Liu WC*, Yang CC, Tsai IJ, Su KP. Refining the understanding of EPA's role in episodic migraine: A response to methodological considerations. Brain Behav Immun. 2024 Jul 16;121:28. doi: 10.1016/j.bbi.2024.07.016. Epub ahead of print. PMID: 39025420. (IF=8.8, Ranking=PSYCHIATRY, 10/276, 3.6%) (Co-first author)
2024	Zailani H, Wang WL, Satyanarayanan SK, Chiu WC, Liu WC, Sung YS, Chang JP, Su KP. Omega-3 Polyunsaturated Fatty Acids and Blood-Brain Barrier Integrity in Major Depressive Disorder: Restoring Balance for Neuroinflammation and Neuroprotection. Yale J Biol Med. 2024 Sep 30;97(3):349-363. doi: 10.59249/YZLQ4631. PMID: 39351324; PMCID: PMC11426295. (IF=2.5, Ranking=BIOLOGY, 37/109, 33.9%)
2024	Kuo LF, Liu WC*, Li MF, Huang FH, Chou CK, Chen TH, Tsai YT, Hsu PI, Li CJ, Wu IT, Tsai KF. Prognostic Evaluation of Conversion Therapy Following Hepatic Arterial Infusion Chemotherapy or Immunotherapy in Patients with Advanced or Transarterial Chemoembolization Unsuitable Intermediate-Stage Hepatocellular Carcinoma-A retrospective cohort study. Oncology. 2024 Oct 28:1-30. doi: 10.1159/000542291. Epub ahead of print. PMID: 39467524. (IF=2.5, Ranking=ONCOLOGY, 183/322, 56.8%) (Co-first author)
2024	Lin YW, Cheng SW, Liu WC, Zailani H, Wu SK, Hung MC, Su KP. Chemogenetic targeting TRPV1 in obesity-induced depression: Unveiling therapeutic potential of eicosapentaenoic acid and acupuncture. Brain Behav Immun. 2024 Oct 23:S0889-1591(24)00669-X. doi: 10.1016/j.bbi.2024.10.028. Epub ahead of print. PMID: 39454693. (IF=8.8, Ranking=PSYCHIATRY, 10/276, 3.6%)
2024	Wu SK, Yang KJ, Liu WC, Malau IA, Zailani H, Chang CH, Huang SY, Chang JPC, Chiu WC, Su KP.The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-blind, Placebo-controlled Pilot Study. Nutrients 2024, 16(21), 3688; doi:10.3390/nu16213688 (IF=3.2, Ranking=NUTRITION & DIETETICS, 50/114, 43.9%)
2024	Chang CM, Tsai IJ, Yang CC, Liu WC*, Yang CP. The Impact of Alpha-s1 Casein Hydrolysate On Chronic Insomnia: A Randomized, Double-Blind Controlled Trial. Clinical Nutrition. (IF=6.6, Ranking=NUTRITION & DIETETICS, 10/114, 8.8%) (Corresponding author)
2024	Zhang F, Han X, Mu Q, Zailani H, Liu WC, Quang LD, Wu Y, Wu N, Kang Y, Su L, Liu Y, Su KP, Wang F. Elevated cerebrospinal fluid biomarkers of neuroinflammation and neuronal damage in essential hypertension with secondary insomnia: implications for Alzheimer's disease risk. Brain Behav Immun. 2024 Dec;125:158-167 doi:10.1016/j.bbi.2024.12.157 (IF=8.8, Ranking=PSYCHIATRY, 10/276, 3.6%)
2023	Wu JS, Hong TC, Wu HT, Lin YJ, Chang TT, Wang CT, Liu WC, Hsieh MT, Wu IC, Chen PJ, Chen CY, Lin SH, Chuang CH, Han MZ, Chen HP, Tsai HM, Kuo HY. Hepatic arterial infusion chemotherapy and immune checkpoint inhibitors, alone or in combination, in advanced hepatocellular carcinoma with macrovascular invasion: a single-centre experience in Taiwan. J Gastrointest Oncol. 2023 Apr 29;14(2):849-862. doi: 10.21037/jgo-22-858. Epub 2023 Apr 10. PMID: 37201085; PMCID: PMC10186549. (IF=2.0, Ranking=GASTROENTEROLOGY & HEPATOLOGY, 90/143, 62.9%)
2023	Chou PH, Liu WC, Lin WH, Hsu CW, Wang SC, Su KP. NIRS-aided differential diagnosis among patients with major depressive disorder, bipolar disorder, and schizophrenia. J Affect Disord. 2023 Nov 15;341:366-373. doi: 10.1016/j.jad.2023.08.101. Epub 2023 Aug 25. PMID: 3763481. (IF=4.9, Ranking=PSYCHIATRY, 38/276, 13.8%)
2023	Chou PH, Liu WC, Wang SC, Lin WH, Chung YL, Chang CH, Su KP. Associations between frontal lobe activity and depressive symptoms in patients with major depressive disorder receiving rTMS treatment: a near-infrared spectroscopy study. Front Psychiatry. 2023 Aug 16;14:1235713. doi: 10.3389/fpsyt.2023.1235713. PMID: 37654993; PMCID: PMC10466407. (IF=3.2, Ranking=PSYCHIATRY, 88/276, 31.9%)
2023	Iqbal AZ, Wu SK, Zailani H, Chiu WC, Liu WC, Su KP, Lee SD. Effects of Omega-3 Polyunsaturated Fatty Acids Intake on Vasomotor Symptoms, Sleep Quality and Depression in Postmenopausal Women: A Systematic Review. Nutrients. 2023 Sep 30;15(19):4231. doi: 10.3390/nu15194231. PMID: 37836515; PMCID: PMC10574492. (IF=3.2, Ranking=NUTRITION & DIETETICS, 50/114, 43.9%)
2022	Tseng CW, Liu WC, Chen CY, Chang TT, Tseng KC. Impact of HCV viremia on HBV biomarkers in patients coinfected with HBV and HCV. BMC Infect Dis. 2022 Apr 9;22(1):351. doi: 10.1186/s12879-022-07326-1. PMID: 35397497; PMCID: PMC8994285. (IF=3.4, Ranking=INFECTIOUS DISEASES, 47/132, 35.6%)
2022	Tseng CW, Liu WC, Ko PH, Chen YC, Tseng KC, Chang TT. The Predictive Role of Hepatitis B Biomarkers on HBV Reactivation following Direct-Acting Antiviral Therapy in HBV/HCV Coinfected Patients. Viruses. 2022 Aug 18;14(8):1812. doi: 10.3390/v14081812. PMID: 36016434; PMCID: PMC9414824. (IF=3.8, Ranking=VIROLOGY, 17/41, 41.5%)
2021	Wu IC, Liu WC*, Chiu YC, Chiu HC, Cheng PN, Chang TT. Clinical Implications of Serum Hepatitis B Virus Pregenomic RNA Kinetics in Chronic Hepatitis B Patients Receiving Antiviral Treatment and Those Achieving HBsAg Loss. Microorganisms. 2021 May 26;9(6):1146. doi: 10.3390/microorganisms9061146. PMID: 34073483; PMCID: PMC8229518 (IF=4.1, Ranking=MICROBIOLOGY, 49/161, 30.4%) (Co-first author)
2020	Liu WC, Wu IC, Chiu YC, Tseng KC, Chen CY, Chiu HC, Cheng PN, Chang TT. Genotyping of immune-related loci associated with delayed HBeAg seroconversion in immune-active chronic hepatitis B patients. Antiviral Res. 2020 Apr;176:104719. doi: 10.1016/j.antiviral.2020.104719. Epub 2020 Jan 28. PMID: 32004619. (IF=4.5, Ranking=PHARMACOLOGY & PHARMACY, 60/354, 16.9%)
2019	Lin TC, Liu WC, Hsu YH, Lin JJ, Chiu YC, Chiu HC, Cheng PN, Chen CY, Chang TT, Wu IC. Insulin Resistance Associated Disorders Pivoting Long-Term Hepatitis B Surface Antigen Decline During Entecavir Therapy. J Clin Med. 2019 Nov 6;8(11):1892. doi: 10.3390/jcm8111892. PMID: 31698809; PMCID: PMC6912775
2018	Lin TC, Chiu YC, Chiu HC, Liu WC, Cheng PN, Chen CY, Chang TT, Wu IC. Clinical utility of hepatitis B surface antigen kinetics in treatment-naïve chronic hepatitis B patients during long-term entecavir therapy. World J Gastroenterol. 2018 Feb 14;24(6):725-736. doi: 10.3748/wjg.v24.i6.725. PMID: 29456411; PMCID: PMC5807675. (IF=3.0, Ranking=MEDICINE, GENERAL & INTERNAL, 58/325, 17.8%)
2018	Wu IC, Liu WC*, Chang TT. Applications of next-generation sequencing analysis for the detection of hepatocellular carcinoma-associated hepatitis B virus mutations. J Biomed Sci. 2018 Jun 2;25(1):51. doi: 10.1186/s12929-018-0442-4. PMID: 29859540; PMCID: PMC5984823. (IF=9.0, Ranking=MEDICINE, RESEARCH & EXPERIMENTAL, 15/189, 7.9%) (Co-first author)
2017	Ho CH, Tsai HW, Lee CY, Huang LJ, Chien RN, Wu IC, Chiu YC, Liu WC, Cheng PN, Chang TT, Chen SH. Favorable Response to Long-term Nucleos(t)ide Analogue Therapy in HBeAg-positive Patients with High Serum Fucosyl-Agalactosyl IgG. Sci Rep. 2017 May 16;7(1):1957. doi: 10.1038/s41598-017-02158-5. PMID: 28512353; PMCID: PMC5434008.
2017	Liu WC, Wu IC, Lee YC, Lin CP, Cheng JH, Lin YJ, Yen CJ, Cheng PN, Li PF, Cheng YT, Cheng PW, Sun KT, Yan SL, Lin JJ, Yang JC, Chang KC, Ho CH, Tseng VS, Chang BC, Wu JC, Chang TT. Hepatocellular carcinoma-associated single-nucleotide variants and deletions identified by the use of genome-wide high-throughput analysis of hepatitis B virus. J Pathol. 2017 Oct;243(2):176-192. doi: 10.1002/path.4938. Epub 2017 Aug 17. PMID: 28696069
2017	Cheng JH, Liu WC, Chang TT, Hsieh SY, Tseng VS. Detecting exact breakpoints of deletions with diversity in hepatitis B viral genomic DNA from next- generation sequencing data. Methods. 2017 Oct 1;129:24-32. doi: 10.1016/j.ymeth.2017.08.005. Epub 2017 Aug 10. PMID: 28802713
2016	Liu WC, Lin CP, Cheng CP, Ho CH, Lan KL, Cheng JH, Yen CJ, Cheng PN, Wu IC, Li IC, Chang BC, Tseng VS, Chiu YC, Chang TT. Aligning to the sample-specific reference sequence to optimize the accuracy of next-generation sequencing analysis for hepatitis B virus. Hepatol Int. 2016 Jan;10(1):147-57. doi: 10.1007/s12072-015-9645-x. Epub 2015 Jul 25. PMID: 26208819; PMCID: PMC4722079
2016	Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase.
2016	DeF-GPU: Efficient and effective deletions finding in hepatitis B viral genomic DNA using a GPU architecture.
2015	Aberrant serum immunoglobulin G glycosylation in chronic hepatitis B is associated with histological liver damage and reversible by antiviral therapy
2014	Efficacy of entecavir in chronic hepatitis B patients with persistently normal alanine aminotransferase: randomized, double-blind, placebo-controlled study.
2014	Association of serum IgG N-glycome and transforming growth factor-β1 with hepatitis B virus e antigen seroconversion during entecavir therapy.
2012	Analysis of precore/core covariances associated with viral kinetics and genotypes in hepatitis B e antigen-positive chronic hepatitis B patients.
2011	Association of intrahepatic cccDNA reduction with the improvement of liver histology in chronic hepatitis B patients receiving oral antiviral agents
2011	Novel nucleotide and amino acid covariation between the 5'UTR and the NS2/NS3 proteins of hepatitis C virus: bioinformatic and functional analyses.
2009	HBV DNA level as an important determinant of E antigen seroconversion of chronic hepatitis B during adefovir dipivoxil therapy.
2008	Genotyping of hepatitis B virus--genotypes a to g by multiplex polymerase chain reaction.
2007	Characterization of viral kinetics in patients with hepatitis B e antigen-positive chronic hepatitis B.
2007	Five subgenotypes of hepatitis B virus genotype B with distinct geographic and virological characteristics.
2006	Simultaneous quantification and genotyping of hepatitis B virus for genotypes A to G by real-time PCR and two-step melting curve analysis
2003	Identification of a ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy

年度	論文名稱
2025	Utilizing WBC Cell Population Data from Hematology Analyzers to Improve the Deletion Rate of Immature Granules
2024	Obesity and Inflammation in Schizophrenic and Bipolar Patients: A Clinical Insight
2024	Prognostic Evaluation of Curative Treatment Following Arterial Chemotherapy or Immunotherapy in Patients with advanced Hepatocellular Carcinoma or Intermediate-Stage HCC Unsuitable for Arterial Embolization

年度	計畫名稱	計畫期間	補助 / 委託或合作機構
2025	精油漱口水能否改善社區老人口腔衛生健康之成效：一項隨機臨床試驗	2025-01 ~ 2025-12	臺南市立安南醫院-委託中國醫藥大學興建經營
2025	評估精油沐浴降低重症加護病房病人泌尿道感染發生之成效：一項隨機臨床試驗	2025-01 ~ 2025-12	臺南市立安南醫院-委託中國醫藥大學興建經營
2025	從肝組織微生物微環境的角度探尋B型肝炎病毒相關肝細胞癌復發的潛在生物標記物(114個-02)	2025-03 ~ 2025-12	國立台南護專-校內專題研究計畫
2024	探析慢性B型肝炎患者血清中細胞游離核醣核酸特性並尋找與自發性B型肝炎病毒表面抗原清除、功能性治癒及停藥後病毒復發的新生物標記及相關機制	2024-08 ~ 2027-07	國科會
2024	探討晝夜節律紊亂對慢性肝病認知障礙的影響：從流行病學分析到生物標記發現的綜合方法	2024-08 ~ 2025-07	臺南市立安南醫院-委託中國醫藥大學興建經營
2024	光生物調節療法在改善阿茲海默症和輕度認知障礙患者認知功能的臨床效能研究	2024-08 ~ 2025-07	臺南市立安南醫院-委託中國醫藥大學興建經營
2024	COVID-19 大流行期間自殺行為和危險因素之全球概述	2024-08 ~ 2025-08	臺南市立安南醫院-委託中國醫藥大學興建經營

發表日期	專利名稱	專利編號
2005-01	以B型肝炎病毒基因序列篩檢肝癌高危險性的方法	104-125AP-TW1

年度	獎項名稱
2024	Poster Presentation Award, 2024, Obesity and inflammation in schizophrenic and bipolar patients: A clinical insight
2024	台南護專-113學年度第1學期教學評量成績優秀教師 (微生物學)
2010	明道大學 99學年度優良教師獎
2009	明道大學 98學年度優良教師獎
2009	明道大學 98學年度優良教師獎
2009	明道大學 98學年度績優導師獎
2008	明道大學 97學年度優良教師獎