國立臺南護理專科學校護理科資訊網

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名稱劉紋君

辦公室電話740

信箱wenchun911@mail.ntin.edu.tw

授課領域微生物(含實驗)

研究專長病毒基因體學、微生物群基因體學、免疫學、生物資訊學、肝炎病毒學、演化學與臨床醫學研究分析

學校名稱	系所	學位	期間
國立成功大學	基礎醫學研究所	博士	2002-08-2007-09
國立成功大學	分子醫學研究所	碩士(直升博士班)	2001-08-2002-07

服務機關名稱	單位	職務	期間
國立臺南護理專科學校	護理科	助理教授	2024-08-迄今
臺南市立安南醫院-委託中國醫藥大學興建經營	教學研究部	博士後研究員	2023-08-2024-07
國立成功大學	醫學院內科	博士後研究員	2012-08-2023-07
國立成功大學	肝臟醫學生物科技研究中心	助研究員	2011-08-2012-07
明道大學	生物科技學系	助理教授	2008-08-2011-07

年度	論文名稱
2024	Microbiota-microglia crosstalk between Blautia producta and neuroinflammation of Parkinson's disease: A bench-to-bedside translational approach.
2024	A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine.
2024	Refining the understanding of EPA's role in episodic migraine: A response to methodological considerations.
2023	Hepatic arterial infusion chemotherapy and immune checkpoint inhibitors, alone or in combination, in advanced hepatocellular carcinoma with macrovascular invasion: a single-centre experience in Taiwan
2023	NIRS-aided differential diagnosis among patients with major depressive disorder, bipolar disorder, and schizophrenia
2023	Associations between frontal lobe activity and depressive symptoms in patients with major depressive disorder receiving rTMS treatment: a near-infrared spectroscopy study.
2023	Effects of Omega-3 Polyunsaturated Fatty Acids Intake on Vasomotor Symptoms, Sleep Quality and Depression in Postmenopausal Women: A Systematic Review.
2022	Impact of HCV viremia on HBV biomarkers in patients coinfected with HBV and HCV.
2022	The Predictive Role of Hepatitis B Biomarkers on HBV Reactivation following Direct-Acting Antiviral Therapy in HBV/HCV Coinfected Patients.
2021	Clinical Implications of Serum Hepatitis B Virus Pregenomic RNA Kinetics in Chronic Hepatitis B Patients Receiving Antiviral Treatment and Those Achieving HBsAg Loss.
2020	Genotyping of immune-related loci associated with delayed HBeAg seroconversion in immune-active chronic hepatitis B patients.
2019	Insulin Resistance Associated Disorders Pivoting Long-Term Hepatitis B Surface Antigen Decline During Entecavir Therapy.
2018	Clinical utility of hepatitis B surface antigen kinetics in treatment-naïve chronic hepatitis B patients during long-term entecavir therapy.
2018	Applications of next-generation sequencing analysis for the detection of hepatocellular carcinoma-associated hepatitis B virus mutations.
2017	Favorable Response to Long-term Nucleos(t)ide Analogue Therapy in HBeAg-positive Patients with High Serum Fucosyl-Agalactosyl IgG.
2017	Hepatocellular carcinoma-associated single-nucleotide variants and deletions identified by the use of genome-wide high-throughput analysis of hepatitis B virus.
2017	Detecting exact breakpoints of deletions with diversity in hepatitis B viral genomic DNA from next- generation sequencing data.
2016	Aligning to the sample-specific reference sequence to optimize the accuracy of next-generation sequencing analysis for hepatitis B virus.
2016	Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase.
2016	DeF-GPU: Efficient and effective deletions finding in hepatitis B viral genomic DNA using a GPU architecture.
2015	Aberrant serum immunoglobulin G glycosylation in chronic hepatitis B is associated with histological liver damage and reversible by antiviral therapy
2014	Efficacy of entecavir in chronic hepatitis B patients with persistently normal alanine aminotransferase: randomized, double-blind, placebo-controlled study.
2014	Association of serum IgG N-glycome and transforming growth factor-β1 with hepatitis B virus e antigen seroconversion during entecavir therapy.
2012	Analysis of precore/core covariances associated with viral kinetics and genotypes in hepatitis B e antigen-positive chronic hepatitis B patients.
2011	Association of intrahepatic cccDNA reduction with the improvement of liver histology in chronic hepatitis B patients receiving oral antiviral agents
2011	Novel nucleotide and amino acid covariation between the 5'UTR and the NS2/NS3 proteins of hepatitis C virus: bioinformatic and functional analyses.
2009	HBV DNA level as an important determinant of E antigen seroconversion of chronic hepatitis B during adefovir dipivoxil therapy.
2008	Genotyping of hepatitis B virus--genotypes a to g by multiplex polymerase chain reaction.
2007	Characterization of viral kinetics in patients with hepatitis B e antigen-positive chronic hepatitis B.
2007	Five subgenotypes of hepatitis B virus genotype B with distinct geographic and virological characteristics.
2006	Simultaneous quantification and genotyping of hepatitis B virus for genotypes A to G by real-time PCR and two-step melting curve analysis
2003	Identification of a ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy

年度	論文名稱
2024	Obesity and Inflammation in Schizophrenic and Bipolar Patients: A Clinical Insight
2024	Prognostic Evaluation of Curative Treatment Following Arterial Chemotherapy or Immunotherapy in Patients with advanced Hepatocellular Carcinoma or Intermediate-Stage HCC Unsuitable for Arterial Embolization

發表日期	專利名稱	專利編號
2005-01	以B型肝炎病毒基因序列篩檢肝癌高危險性的方法	104-125AP-TW1

年度	獎項名稱
99	明道大學 99學年度優良教師獎
98-2	明道大學 98學年度優良教師獎
98-1	明道大學 98學年度優良教師獎
97-1	明道大學 97學年度優良教師獎
98	明道大學 98學年度績優導師